Impact of drug reconciliation at discharge and communication between hospital and community pharmacists on drug-related problems: study protocol for a randomized controlled trial
Identifieur interne : 000341 ( Main/Exploration ); précédent : 000340; suivant : 000342Impact of drug reconciliation at discharge and communication between hospital and community pharmacists on drug-related problems: study protocol for a randomized controlled trial
Auteurs : Xavier Pourrat [France] ; Clarisse Roux [France] ; Brigitte Bouzige [France] ; Valérie Garnier [France] ; Armelle Develay [France] ; Benoit Allenet [France] ; Martial Fraysse [France] ; Jean-Michel Halimi [France] ; Jacqueline Grassin [France] ; Bruno Giraudeau [France]Source :
- Trials [ 1745-6215 ] ; 2014.
Abstract
Patients are at risk of drug-related problems (DRPs) at transition points during hospitalization. The community pharmacist (CP) is often the first healthcare professional patients visit after discharge. CPs lack sufficient information about the patient and so they may be unable to identify problems in medications, which may lead to dispensing the wrong drugs or dosage, and/or giving wrong information. We aim to assess the impact of a complex intervention comprising of medication reconciliation performed at discharge by a hospital pharmacist (HP) with communication between the HP and CP on DRPs during the seven days following discharge.
The study is a cluster randomized crossover trial involving 46 care units (each unit corresponding to a cluster) in 22 French hospitals during two consecutive 14-day periods, randomly assigned as ‘experimental’ or ‘control’ (usual care) periods. We will recruit patients older than 18 years of age and visiting the same CP for at least three months. We will exclude patients with a hospital length of stay of more than 21 days, who do not return home or those in palliative care. During the experimental period, the HP will perform a medications reconciliation that will be communicated to the patient. The HP will inform the patient’s CP about the patient’s drug therapy (modification in home medication, acute drugs prescribed, nonprescription treatments, and/or lab results). The primary outcome will be a composite outcome of any kind of drug misuse during the seven days following discharge assessed at day seven (±2) post-discharge by a pharmacist in charge of the study who will contact both patients and CPs by phone. The secondary outcome will be unplanned hospitalizations assessed by phone contact at day 35 (±5) after discharge. We plan to recruit 1,176 patients.
This study will assess the impact of a reconciliation of medications performed at patient discharge followed by communication between the HP and the patient’s CP. It will allow for identifying the type of patients in France for which the intervention is most relevant.
This study was registered with ClinicalTrials.gov (number:
Url:
DOI: 10.1186/1745-6215-15-260
PubMed: 24981605
PubMed Central: 4226949
Affiliations:
- France
- Auvergne-Rhône-Alpes, Centre-Val de Loire, Languedoc-Roussillon, Occitanie (région administrative), Rhône-Alpes, Région Centre, Île-de-France
- Fontenay-sous-Bois, La Tronche, Les Salles du Gardon, Meynes, Nîmes, Saint-Martin-d'Hères, Tours
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Le document en format XML
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wicri:level="3"><nlm:aff id="I1">Pharmacy Department, Pharm D, Tours University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 09, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pharmacy Department, Pharm D, Tours University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Roux, Clarisse" sort="Roux, Clarisse" uniqKey="Roux C" first="Clarisse" last="Roux">Clarisse Roux</name><affiliation wicri:level="3"><nlm:aff id="I2">Pharmacy Department, Pharm D, Nîmes University Hospital, 4 Rue du Professeur Robert Debré, 30029 Nîmes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pharmacy Department, Pharm D, Nîmes University Hospital, 4 Rue du Professeur Robert Debré, 30029 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first="Valérie" last="Garnier">Valérie Garnier</name><affiliation wicri:level="3"><nlm:aff id="I4">Pharm D, Pharmacien, Pharmacie Garnier, 1 Chemin des Prés, 30840 Meynes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pharm D, Pharmacien, Pharmacie Garnier, 1 Chemin des Prés, 30840 Meynes</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Meynes</settlement></placeName></affiliation></author><author><name sortKey="Develay, Armelle" sort="Develay, Armelle" uniqKey="Develay A" first="Armelle" last="Develay">Armelle Develay</name><affiliation wicri:level="3"><nlm:aff id="I2">Pharmacy Department, Pharm D, Nîmes University Hospital, 4 Rue du Professeur Robert Debré, 30029 Nîmes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pharmacy Department, Pharm D, Nîmes University Hospital, 4 Rue du Professeur 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5525), School of Medicine and Pharmacy, J Fourier University, Grenoble, 621 Avenue Centrale, 38041 Saint-Martin-d'Hères, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>ThEMAS TIMC-IMAG (UMR CNRS 5525), School of Medicine and Pharmacy, J Fourier University, Grenoble, 621 Avenue Centrale, 38041 Saint-Martin-d'Hères</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Martin-d'Hères</settlement></placeName></affiliation></author><author><name sortKey="Fraysse, Martial" sort="Fraysse, Martial" uniqKey="Fraysse M" first="Martial" last="Fraysse">Martial Fraysse</name><affiliation wicri:level="3"><nlm:aff id="I6">Pharm D, 52 Rue du Commandant Jean Duhail, 94120 Fontenay-sous-Bois, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pharm D, 52 Rue du Commandant Jean Duhail, 94120 Fontenay-sous-Bois</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Fontenay-sous-Bois</settlement></placeName></affiliation></author><author><name sortKey="Halimi, Jean Michel" sort="Halimi, Jean Michel" uniqKey="Halimi J" first="Jean-Michel" last="Halimi">Jean-Michel Halimi</name><affiliation wicri:level="3"><nlm:aff id="I7">Nephrology Department, Tours University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 09, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Nephrology Department, Tours University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I10">Therapeutic Department, School of Medicine, François Rabelais University, 10 Boulevard Tonnellé, 37000 Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Therapeutic Department, School of Medicine, François Rabelais University, 10 Boulevard Tonnellé, 37000 Tours</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Grassin, Jacqueline" sort="Grassin, Jacqueline" uniqKey="Grassin J" first="Jacqueline" last="Grassin">Jacqueline Grassin</name><affiliation wicri:level="3"><nlm:aff id="I1">Pharmacy Department, Pharm D, Tours University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 09, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Pharmacy Department, Pharm D, Tours University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Giraudeau, Bruno" sort="Giraudeau, Bruno" uniqKey="Giraudeau B" first="Bruno" last="Giraudeau">Bruno Giraudeau</name><affiliation wicri:level="3"><nlm:aff id="I8">INSERM CIC 1415, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours Cedex 09, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM CIC 1415, CHRU de Tours, Hôpital Bretonneau, 2 Boulevard Tonnellé, 37044 Tours Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I11">INSERM CIC 1415, François Rabelais University, 10 Boulevard Tonnellé, 37000 Tours, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM CIC 1415, François Rabelais University, 10 Boulevard Tonnellé, 37000 Tours</wicri:regionArea><placeName><region type="region" nuts="2">Centre-Val de Loire</region><region type="old region" nuts="2">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author></analytic><series><title level="j">Trials</title><idno type="eISSN">1745-6215</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Patients are at risk of drug-related problems (DRPs) at transition points during hospitalization. The community pharmacist (CP) is often the first healthcare professional patients visit after discharge. CPs lack sufficient information about the patient and so they may be unable to identify problems in medications, which may lead to dispensing the wrong drugs or dosage, and/or giving wrong information. We aim to assess the impact of a complex intervention comprising of medication reconciliation performed at discharge by a hospital pharmacist (HP) with communication between the HP and CP on DRPs during the seven days following discharge.</p></sec><sec><title>Methods/Design</title><p>The study is a cluster randomized crossover trial involving 46 care units (each unit corresponding to a cluster) in 22 French hospitals during two consecutive 14-day periods, randomly assigned as ‘experimental’ or ‘control’ (usual care) periods. We will recruit patients older than 18 years of age and visiting the same CP for at least three months. We will exclude patients with a hospital length of stay of more than 21 days, who do not return home or those in palliative care. During the experimental period, the HP will perform a medications reconciliation that will be communicated to the patient. The HP will inform the patient’s CP about the patient’s drug therapy (modification in home medication, acute drugs prescribed, nonprescription treatments, and/or lab results). The primary outcome will be a composite outcome of any kind of drug misuse during the seven days following discharge assessed at day seven (±2) post-discharge by a pharmacist in charge of the study who will contact both patients and CPs by phone. The secondary outcome will be unplanned hospitalizations assessed by phone contact at day 35 (±5) after discharge. We plan to recruit 1,176 patients.</p></sec><sec><title>Discussion</title><p>This study will assess the impact of a reconciliation of medications performed at patient discharge followed by communication between the HP and the patient’s CP. It will allow for identifying the type of patients in France for which the intervention is most relevant.</p></sec><sec><title>Trial registration</title><p>This study was registered with ClinicalTrials.gov (number: <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/show/NCT02006797">NCT02006797</ext-link>) on 5 December 2013.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Mil, Jw" uniqKey="Van Mil J">JW Van Mil</name></author><author><name sortKey="Westerlund, Lo" uniqKey="Westerlund L">LO Westerlund</name></author><author><name sortKey="Hersberger, Ke" uniqKey="Hersberger K">KE Hersberger</name></author><author><name sortKey="Schaefer, Ma" uniqKey="Schaefer M">MA Schaefer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Corneau, H" uniqKey="Corneau H">H Corneau</name></author><author><name sortKey="Dorval, E" uniqKey="Dorval E">E Dorval</name></author><author><name sortKey="Rosset, P" uniqKey="Rosset P">P Rosset</name></author><author><name sortKey="Hay, N" uniqKey="Hay N">N Hay</name></author><author><name sortKey="Guegan, F" uniqKey="Guegan F">F Guegan</name></author><author><name sortKey="Grassin, J" uniqKey="Grassin J">J Grassin</name></author><author><name sortKey="Pourrat, X" uniqKey="Pourrat X">X Pourrat</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pourrat, X" uniqKey="Pourrat X">X Pourrat</name></author><author><name sortKey="Corneau, H" uniqKey="Corneau H">H Corneau</name></author><author><name sortKey="Floch, S" uniqKey="Floch S">S Floch</name></author><author><name sortKey="Kuzzay, Mp" uniqKey="Kuzzay M">MP Kuzzay</name></author><author><name sortKey="Favard, F" uniqKey="Favard F">F Favard</name></author><author><name sortKey="Rosset, P" uniqKey="Rosset P">P Rosset</name></author><author><name sortKey="Hay, N" uniqKey="Hay N">N Hay</name></author><author><name sortKey="Grassin, J" uniqKey="Grassin J">J Grassin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, Pc" uniqKey="Walker P">PC Walker</name></author><author><name sortKey="Bernstein, Sj" uniqKey="Bernstein S">SJ Bernstein</name></author><author><name sortKey="Jones, Jn" uniqKey="Jones J">JN Jones</name></author><author><name sortKey="Piersma, J" uniqKey="Piersma J">J Piersma</name></author><author><name sortKey="Kim, Hw" uniqKey="Kim H">HW Kim</name></author><author><name sortKey="Regal, Re" uniqKey="Regal R">RE Regal</name></author><author><name sortKey="Kuhn, L" uniqKey="Kuhn L">L Kuhn</name></author><author><name sortKey="Flanders, Sa" uniqKey="Flanders S">SA Flanders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brulebois, A" uniqKey="Brulebois A">A Brulebois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chevremont, L" uniqKey="Chevremont L">L Chevremont</name></author><author><name sortKey="Blandin, M" uniqKey="Blandin M">M Blandin</name></author><author><name sortKey="Corneau, H" uniqKey="Corneau H">H Corneau</name></author><author><name sortKey="Perarnau, J M" uniqKey="Perarnau J">J-M Perarnau</name></author><author><name sortKey="Grassin, J" uniqKey="Grassin J">J Grassin</name></author><author><name sortKey="Pourrat, X" uniqKey="Pourrat X">X Pourrat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boockvar, Ks" uniqKey="Boockvar K">KS Boockvar</name></author><author><name sortKey="Carlson Lacorte, H" uniqKey="Carlson Lacorte H">H Carlson LaCorte</name></author><author><name sortKey="Giambanco, V" uniqKey="Giambanco V">V Giambanco</name></author><author><name sortKey="Fridman, B" uniqKey="Fridman B">B Fridman</name></author><author><name sortKey="Siu, A" uniqKey="Siu A">A Siu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karapinar Carkit, F" uniqKey="Karapinar Carkit F">F Karapinar-Carkit</name></author><author><name sortKey="Borgsteede, Sd" uniqKey="Borgsteede S">SD Borgsteede</name></author><author><name sortKey="Zoer, J" uniqKey="Zoer J">J Zoer</name></author><author><name sortKey="Smit, Hj" uniqKey="Smit H">HJ Smit</name></author><author><name sortKey="Egberts, Ac" uniqKey="Egberts A">AC Egberts</name></author><author><name sortKey="Van Den Bemt, Pm" uniqKey="Van Den Bemt P">PM van den Bemt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Climente Marti, M" uniqKey="Climente Marti M">M Climente-Martí</name></author><author><name sortKey="Garcia Ma N, Er" uniqKey="Garcia Ma N E">ER García-Mañón</name></author><author><name sortKey="Artero Mora, A" uniqKey="Artero Mora A">A Artero-Mora</name></author><author><name sortKey="Jimenez Torres, Nv" uniqKey="Jimenez Torres N">NV Jiménez-Torres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimes, Tc" uniqKey="Grimes T">TC Grimes</name></author><author><name sortKey="Duggan, Ca" uniqKey="Duggan C">CA Duggan</name></author><author><name sortKey="Delaney, Tp" uniqKey="Delaney T">TP Delaney</name></author><author><name sortKey="Graham, Im" uniqKey="Graham I">IM Graham</name></author><author><name sortKey="Conlon, Kc" uniqKey="Conlon K">KC Conlon</name></author><author><name sortKey="Deasy, E" uniqKey="Deasy E">E Deasy</name></author><author><name sortKey="Jago Byrne, Mc" uniqKey="Jago Byrne M">MC Jago-Byrne</name></author><author><name sortKey="O Brien, P" uniqKey="O Brien P">P O’ Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggink, Rn" uniqKey="Eggink R">RN Eggink</name></author><author><name sortKey="Lenderink, Aw" uniqKey="Lenderink A">AW Lenderink</name></author><author><name sortKey="Widdershoven, Jw" uniqKey="Widdershoven J">JW Widdershoven</name></author><author><name sortKey="Van Den Bemt, Pm" uniqKey="Van Den Bemt P">PM van den Bemt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, M" uniqKey="Carter M">M Carter</name></author><author><name sortKey="Allin, D" uniqKey="Allin D">D Allin</name></author><author><name sortKey="Scott, La" uniqKey="Scott L">LA Scott</name></author><author><name sortKey="Grauer, D" uniqKey="Grauer D">D Grauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nester, T" uniqKey="Nester T">T Nester</name></author><author><name sortKey="Hale, L" uniqKey="Hale L">L Hale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, J" uniqKey="Cohen J">J Cohen</name></author><author><name sortKey="Wilson, C" uniqKey="Wilson C">C Wilson</name></author><author><name sortKey="Ward, F" uniqKey="Ward F">F Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawson, P" uniqKey="Dawson P">P Dawson</name></author><author><name sortKey="Gray, S" uniqKey="Gray S">S Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duran Garcia, E" uniqKey="Duran Garcia E">E Durán-García</name></author><author><name sortKey="Fernandez Llamazares, Cm" uniqKey="Fernandez Llamazares C">CM Fernandez-Llamazares</name></author><author><name sortKey="Calleja Hernandez, Ma" uniqKey="Calleja Hernandez M">MA Calleja-Hernández</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bolas, H" uniqKey="Bolas H">H Bolas</name></author><author><name sortKey="Brookes, K" uniqKey="Brookes K">K Brookes</name></author><author><name sortKey="Scott, M" uniqKey="Scott M">M Scott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hugtenburg, Jg" uniqKey="Hugtenburg J">JG Hugtenburg</name></author><author><name sortKey="Borgsteede, Sd" uniqKey="Borgsteede S">SD Borgsteede</name></author><author><name sortKey="Beckeringh, J" uniqKey="Beckeringh J">J Beckeringh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donner, A" uniqKey="Donner A">A Donner</name></author><author><name sortKey="Klar, N" uniqKey="Klar N">N Klar</name></author><author><name sortKey="Zou, G" uniqKey="Zou G">G Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bayliff, C" uniqKey="Bayliff C">C Bayliff</name></author><author><name sortKey="Einarson, T" uniqKey="Einarson T">T Einarson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boutron, I" uniqKey="Boutron I">I Boutron</name></author><author><name sortKey="Guittet, L" uniqKey="Guittet L">L Guittet</name></author><author><name sortKey="Estellat, C" uniqKey="Estellat C">C Estellat</name></author><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Hr Bjartsson, A" uniqKey="Hr Bjartsson A">A Hróbjartsson</name></author><author><name sortKey="Ravaud, P" uniqKey="Ravaud P">P Ravaud</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Giraudeau, B" uniqKey="Giraudeau B">B Giraudeau</name></author><author><name sortKey="Ravaud, P" uniqKey="Ravaud P">P Ravaud</name></author><author><name sortKey="Donner, A" uniqKey="Donner A">A Donner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gulliford, Mc" uniqKey="Gulliford M">MC Gulliford</name></author><author><name sortKey="Adams, G" uniqKey="Adams G">G Adams</name></author><author><name sortKey="Ukoumunne, Oc" uniqKey="Ukoumunne O">OC Ukoumunne</name></author><author><name sortKey="Latinovic, R" uniqKey="Latinovic R">R Latinovic</name></author><author><name sortKey="Chinn, S" uniqKey="Chinn S">S Chinn</name></author><author><name sortKey="Campbell, Mj" uniqKey="Campbell M">MJ Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Rm" uniqKey="Turner R">RM Turner</name></author><author><name sortKey="White, Ir" uniqKey="White I">IR White</name></author><author><name sortKey="Croudace, T" uniqKey="Croudace T">T Croudace</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Centre-Val de Loire</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Rhône-Alpes</li><li>Région Centre</li><li>Île-de-France</li></region><settlement><li>Fontenay-sous-Bois</li><li>La Tronche</li><li>Les Salles du Gardon</li><li>Meynes</li><li>Nîmes</li><li>Saint-Martin-d'Hères</li><li>Tours</li></settlement></list><tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Pourrat, Xavier" sort="Pourrat, Xavier" uniqKey="Pourrat X" first="Xavier" last="Pourrat">Xavier Pourrat</name></region><name sortKey="Allenet, Benoit" sort="Allenet, Benoit" uniqKey="Allenet B" first="Benoit" last="Allenet">Benoit Allenet</name><name sortKey="Allenet, Benoit" sort="Allenet, Benoit" uniqKey="Allenet B" first="Benoit" last="Allenet">Benoit Allenet</name><name sortKey="Bouzige, Brigitte" sort="Bouzige, Brigitte" uniqKey="Bouzige B" first="Brigitte" last="Bouzige">Brigitte Bouzige</name><name sortKey="Develay, Armelle" sort="Develay, Armelle" uniqKey="Develay A" first="Armelle" last="Develay">Armelle Develay</name><name sortKey="Fraysse, Martial" sort="Fraysse, Martial" uniqKey="Fraysse M" first="Martial" last="Fraysse">Martial Fraysse</name><name sortKey="Garnier, Valerie" sort="Garnier, Valerie" uniqKey="Garnier V" first="Valérie" last="Garnier">Valérie Garnier</name><name sortKey="Giraudeau, Bruno" sort="Giraudeau, Bruno" uniqKey="Giraudeau B" first="Bruno" last="Giraudeau">Bruno Giraudeau</name><name sortKey="Giraudeau, Bruno" sort="Giraudeau, Bruno" uniqKey="Giraudeau B" first="Bruno" last="Giraudeau">Bruno Giraudeau</name><name sortKey="Grassin, Jacqueline" sort="Grassin, Jacqueline" uniqKey="Grassin J" first="Jacqueline" last="Grassin">Jacqueline Grassin</name><name sortKey="Halimi, Jean Michel" sort="Halimi, Jean Michel" uniqKey="Halimi J" first="Jean-Michel" last="Halimi">Jean-Michel Halimi</name><name sortKey="Halimi, Jean Michel" sort="Halimi, Jean Michel" uniqKey="Halimi J" first="Jean-Michel" last="Halimi">Jean-Michel Halimi</name><name sortKey="Roux, Clarisse" sort="Roux, Clarisse" uniqKey="Roux C" first="Clarisse" last="Roux">Clarisse Roux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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